Involvement of a cell wall receptor in the mode of action of an anti-Candida toxin of Pichia anomala.
AUTOR(ES)
Sawant, A D
RESUMO
Hanes-Woolf, Dixon, and Hill plots of growth rates of Candida albicans RC1 grown in various concentrations of glucose and a Pichia anomala WC65 toxin suggested the presence of toxin-binding sites. Indirect immunofluorescence microscopy with antitoxin antibodies demonstrated binding of the toxin to the cell wall. Resistance to the toxin of a mutant Saccharomyces cerevisiae deficient in cell wall beta-1-6-D-glucan suggests that the glucan either served as the receptor or influenced the number or composition of the receptor. Immunofluorescence that appeared to be associated with the cell membrane of toxin-treated spheroplasts of C. albicans was also observed. Spheroplasts of the resistant mutant of S. cerevisiae were sensitive to the toxin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=175976Documentos Relacionados
- Purification and characterization of the anti-Candida toxin of Pichia anomala WC 65.
- Anti-Candida albicans activity of Pichia anomala as determined by a growth rate reduction assay.
- Vaginal and Oral Epithelial Cell Anti-Candida Activity
- Anti-Candida Activity of a New Platinum Derivative
- Diagnostic value of anti-Candida enolase antibodies.
