Anti-Candida Activity of a New Platinum Derivative
AUTOR(ES)
Watanabe, T.
FONTE
American Society for Microbiology
RESUMO
A new platinum derivative of the form H[Pt(IV)(Hdigly)Cl2(OH)2] (Hdigly⩵glycylglycine) damaged the Candida albicans cell membrane and inhibited the growth of the cells. The cytotoxic activity of H[Pt(IV)(Hdigly)Cl2(OH)2] on mammalian cells was 10-fold lower than that of cis-diammine-dichloroplatinum (cisplatin). Substitution of platinum for peptides is effective for enhancement of antifungal activity and reduction of the toxicity to mammalian cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90162Documentos Relacionados
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