Interferon immunosuppression: mediation by a suppressor factor.
Johnson, H M
Suppression of the in vitro antibody response to sheep erythrocytes by mouse fibroblast interferon occurred by induction of suppressor cell activity in spleen cells. The suppressor cells produced a soluble factor which mediated the immunosuppression. The suppressor factor did not inhibit virus replication; thus, interferon probably regulates the B-cell response by a mechanism that is different from its antiviral effect.
ACESSO AO ARTIGOhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=551116
- Viral immunosuppression: disabling the guards
- The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor.
- Beta interferon subtype 1 induction by tumor necrosis factor.
- Inhibition of murine nephritogenic effector T cells by a clone-specific suppressor factor.
- Regulation of herpes simplex virus-specific cell-mediated immunity by a specific suppressor factor.