Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

AUTOR(ES)

COSTA-SILVA, DANYLO R., BARROS-OLIVEIRA, MARIA DA CONCEIÇÃO, BORGES, RAFAEL S., TAVARES, CLÉCITON B., BORGES, UMBELINA S., ALVES-RIBEIRO, FRANCISCO A., SILVA, VLADIMIR C., SILVA, BENEDITO B. DA

FONTE

An. Acad. Bras. Ciênc.

DATA DE PUBLICAÇÃO

01/12/2016

RESUMO

ABSTRACT Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk. A growing number of studies support an association between IGF-1 gene polymorphism and breast cancer risk with conflicting results, nevertheless elucidation of the patterns of IGF-1 gene expression may permit characterization of women at high-risk for breast cancer, as well as the development of strategies for early diagnosis and efficient treatment against the disease.

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