Inhibition of muscle differentiation by trypanosoma cruzi.

AUTOR(ES)

Rowin, K S

RESUMO

L6E9 rat myoblasts were infected in tissue culture with the myotropic Brazil strain of Trypanosoma cruzi. The effect of parasite infection on the ability of myoblasts to differentiate into myotubes was studied. Both morphological and biochemical differentiation were found to be profoundly affected by parasitic infection in a dose-related fashion. Evidence is presented to suggest that infected myoblasts can no longer differentiate. Differentiation, once underway, seemed unaffected by the parasitic infection; biochemical markers of differentiation remained intact.

Documentos Relacionados

• Mammalian cell sialic acid enhances invasion by Trypanosoma cruzi.
• Genetics of murine resistance to Trypanosoma cruzi.
• Susceptibility of radiation chimeras to Trypanosoma cruzi.
• Immunocytochemical localization of neuraminidase in Trypanosoma cruzi.
• Transportador ABC e resistência a benznidazol em Trypanosoma cruzi.