Influencia do sexo e do ciclo estral sobre a dor e a inflamação da ATM de ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

Epidemiologycal studies have demonstrated that the prevalence of temporomandibular disfunction (TMD) for women and men is in a ratio of 2.5 to 1. However the influence of gonadal hormones over TMD in women is not completely understood yet. The aim of this study was to verify the influence of sex, estrous cycle and 17 b-estradiol hormone over pain and inflammatory process of the temporomandibular joint (TMJ). Wistar rats (males, females at estrus, females at proestrus and castrated females with and without estrogen replacement) were submitted to nociceptive and inflammatory tests: 1) TMJ formalin test, 2) masticatory incapacity induced by carrageenan and 3) neurogenic plasma extravasation of periarticular TMJ tissue induced by mustard oil test. Statistical analysis was performed using the following tests: t, paired t, ANOVA and Newman-Keuls; the limit of significance was set at 5% (p <0.05). The obtained results from the three experimental tests were respectively: 1) females at estrus and castrated were more sensible to the TMJ formalin test than females at proestrus. Castrated females with estrogen replacement were less sensible than castrated females without estrogen replacement. 2) females at estrus and proestrus and castrated showed a reduction in food intake of respectively 84,0, 83,3 and 49,4%. For males, this reduction was of 48,3%. 3) In the plasmatic extravasation induced by mustard oil, there was no difference among males, females at estrus and proestrus. It can be concluded that, in rats: 1) the sensibility to the TMJ formalin test is affected by hormonal fluctuations of estrous cycle and by 17 b-estradiol replacement in the castrated females; 2) the higher sensibility to allodynia of the tmj (carrageenan test) of females than of males is due to production of ovarian hormones and 3) neurogenic plasma extravasation of TMJ does not depend on the gender and estrous cycle

ASSUNTO(S)

articulação temporomandibular castração estrogenos

ACESSO AO ARTIGO

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