Influência de agentes suspensores e edulcorantes na suspensão de estearato de eritromicina / Influence of suspending agents and sweeteners in erithromycin stearate suspension

AUTOR(ES)
DATA DE PUBLICAÇÃO

1985

RESUMO

Suspensions of erithromycin stearate of national origin present the inconvenience of the high viscosity or of the flotation of the dispersed drug. Different pharmaceutical helpers were studied in order to verify of the erythromycin stearate suspension. BoniasolR2600 (sodium carboxymethyl cellulose), VeegumR HV (aluminum magnesium silicate) and ViscosolR RV (sodium starch glycollate) were used as suspending agents and glycerin, sorbitol at 70% and sucrose were used as sweeteners. Analytic determination to evaluate the suspensions stability were: pH, density, viscosity, aspecto of suspension, volume of the dispersed drug, resuspension characteristics and determination of the antibiotic dose. Suspensions containing BoniasolR 2600 and glycerin or sorbitol didnt present floatation. Preparation with veegumR HV and glycerin or sorbitol in a concentration of 30% (p/v) presented adequate stability.

ASSUNTO(S)

boniasol 2600 boniasol 2600 erithromycin stearate suspension glicerina glycerin sacarose sorbitol 70% sorbitol 70% sucrose suspensão (formas farmacêuticas) suspensão de estearato de eritromicina suspension (pharmaceutical forms) veegum hv veegum hv viscosol rv viscosol rv

ACESSO AO ARTIGO

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