Influência da administração local de sinvastatina na reparação óssea em calvária de ratos

AUTOR(ES)

Jimmy Cavalcanti Calixto

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

16/07/2007

RESUMO

Several therapeutic alternatives have been proposed for the healing of bone defects, associated to the surgery, like autogenous, allogeneous and aloplastic grafts, plasma rich in plaques and some drugs. Recently several works were published reporting correlation between the use of statins, drugs used to reduce the level of blood cholesterol, and bone neoformation. The aim of this work was to evaluate the effect of the treatment with simvastatin, locally administered, in the healing of rat calvarial bone defects. There were used 48 rats, in which there were made two bone defects of 5 mm of diameter, one in each parietal bone. The animals were divided in three groups according to the material used in the defect: control, in which the defect was not treated; simvastatin, sponge of collagen soaked with simvastatin; and carrier, sponge of collagen and distilled water. The sacrifice took place after thirty or sixty days; the skulls were removed, subjected to radiographic examinations and to the routine histological preparation, then histometric analysis of the area of the bone defect was carried out, with support of a software for analysis of images. The data were subjected to the ANOVA and test t of Student. Both in the densiometric and in histometric analysis, it was verified the absence of statistical difference between the three groups, in each experimental period. At sixty days, the control animals presented more bone formation than in thirty days, which did not happen with those who received simvastatin or just the carrier. Clinically, it was verified formation of necrotic crust in the animals of the simvastatin group. One concluded, according to the methodology used, that the simvastatin administered locally harmed the repair of experimental defects in calvaria of rats.

ASSUNTO(S)

densitometry histomorfometry sinvastatina reparo ósseo densitometria histomorfometria simvastatin bone repair odontologia

Documentos Relacionados

• Influência da associação da sinvastatina à matriz de osso desmineralizado bovino na reparação de defeitos ósseos em calvária de ratos
• Ação local do alendronato sódico na reparação óssea de ratos espontaneamente hipertensos (SHR)
• Efeitos da sinvastatina na hipertrofia lipídica da medula óssea induzida pelo uso de corticóides em ratos
• Plasma rico em plaquetas na reparação óssea em tíbias irradiadas de ratos Wistar
• Efeito do selenito de sodio na reparação ossea em tibias de ratos irradiados