Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus.
AUTOR(ES)
Roos, R P
RESUMO
The DA strain and other members of the TO subgroup of Theiler's murine encephalomyelitis viruses cause a persistent demyelinating infection, whereas the GDVII strain and other GDVII subgroup strains cause an acute lethal polioencephalomyelitis. We generated an infectious DA cDNA clone inserted into a transcription vector. Virus derived from transfection of transcripts produced a demyelinating disease indistinguishable from that of wild-type virus. The infectious clone provides a critical reagent for the production of interstrain recombinant viruses to help identify genetic loci responsible for the biological activities of the strains.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=251223Documentos Relacionados
- Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.
- Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus.
- Polyprotein processing of Theiler's murine encephalomyelitis virus.
- Characterization of a cell culture persistently infected with the DA strain of Theiler's murine encephalomyelitis virus.
- Cap-independent translation by the 5' untranslated region of Theiler's murine encephalomyelitis virus.
