Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.
AUTOR(ES)
Zhang, L
RESUMO
Strain GDVII and other members of the GDVII subgroup of Theiler's murine encephalomyelitis virus are highly neurovirulent and rapidly fatal, while strain DA and other members of the TO subgroup produce a chronic, demyelinating disease. GDVII/DA chimeric cDNA studies suggest that a major neurovirulence determinant is within the GDVII 1B through 1D capsid protein coding region, although the additional presence of upstream GDVII sequences, including the 5' untranslated region, contributes to full neurovirulence. Our studies indicate that there are limitations in precisely delineating neurovirulence determinants with chimeric cDNAs between evolutionarily diverged viruses, such as GDVII and DA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=237815Documentos Relacionados
- Influence of Theiler's murine encephalomyelitis virus 5' untranslated region on translation and neurovirulence.
- Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus.
- Assembly of Theiler's virus recombinants used in mapping determinants of neurovirulence.
- Polyprotein processing of Theiler's murine encephalomyelitis virus.
- A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.
