Infecções hospitalares em pacientes submetidos a transplante de fígado: fatores de risco relacionados ao doador / Hospital Infection in liver transplantation

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Early infection after liver transplantation is an important cause for morbidity and mortality. The risk of transmission of microorganisms from the donor to the receptor is reported and is more probable when neither donor nor receptor are treated for the infection. The detection of infection in donors is difficult and usually not available, so indirect information about that infection may be useful at the time the liver is selected or denied, especially in light of lack of organs available for transplantation. We analyzed patients who underwent liver transplantation at the Clinics Hospital of School of Medicine of USP, from January 2002 to June 2005. The exclusion criteria were: death with less then 48 hours, living-donor transplant, re-transplant in less then 5 days and domino transplant. The risk factors evaluated were related to donor and receptor features. The univariate analysis was performed using chisquared test and Fisher exact test for dichotomic variables and Mann-Whitney test for continuous variables. The multivariate analysis was made by stepwise logistic regression. In this period 130 transplants were performed, from which 30 were excluded. A total of 100 transplants in 94 patients were analyzed. We identified 104 infections in 59 transplants. The two most frequent sites of infection were surgical site infection (SSI) - 35% - and primary bloodstream infections (BSI) - 30%. The most prevalent agent was S.aureus - 18% of the agents, but the Gram negatives bacteria were the most common group. The risk factors identified for infection in liver transplant patients in the first month were: antibiotic use by donor for more than 3 days, reoperation post-transplant, dialysis post-transplant, fulminant hepatitis and corticoid treatment for rejection. The microorganisms most frequently isolated in SSI were Gram positive bacteria (56%). The risk factors associated to SSI were: antibiotic use by donor for more than 3 days, transfusion of more than 4 units of blood during the surgery and dialysis post-transplant. The two microorganisms most frequently isolated in BSI were A. baumanni (21%) and coagulase negative Staphylococcus (21%). The risk factors identified for this specific infection site were fulminant hepatitis and dialysis post-transplant. The S. aureus was the most frequent agent, found in 17 cases. 42% of the patients with infection for this bacteria died during the hospitalization. The risk factors associated to S. aureus infection were norepinephrine use by donor and number of blood units transfused.

ASSUNTO(S)

tissue donors transplante de fígado doadores de órgãos infecção hospitalar risk factors liver transplantation fatores de risco cross infection

ACESSO AO ARTIGO

Documentos Relacionados