Infecção pelo herpesvírus 8 humano (HHV-8) em populações indígenas e não indígenas da Amazônia brasileira / Human herpesvirus-8 infection in amerindian and non-amerindian populations in the brazilian Amazon region

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Human herpes virus type 8 (HHV-8) is hyperendemic in Amerindian populations, but its modes of transmission are unknown. Objectives: 1. Study the Human Herpesvirus-8 Infection and Oral Shedding in Amerindian and Non-Amerindian Populations in the Brazilian Amazon Region. 2. Methods: Antibodies against either HHV-8 latency-associated nuclear antigen (LANA) or HHV-8 lytic antigen were detected, by immunofluorescence assays, in 339 Amerindians and 181 non-Amerindians from the Brazilian Amazon. Serological markers of oro-fecal (hepatitis A), parenteral (hepatitis B and C), and sexual (herpes simplex virus type 2 and syphilis) transmission were measured by specific ELISA. Salivary HHV-8 DNA was detected by use of a nested polymerase chain reaction assay and was sequenced. Results: Antibodies against either LANA antigen or lytic were detected in 79.1% of Amerindians and in 6.1% of non-Amerindians. HHV-8 seroprevalence increased with age among Amerindians and already had high prevalence in childhood but was not sex specific in either population. The 2 populations did not differ in seroprevalence of oro-fecal or parenteral markers, but seroprevalence of markers of sexual transmission was lower among Amerindians. HHV-8 DNA in saliva was detected in 23 % of HHV-8 seropositive Amerindians. Detection of HHV-8 decreased with age and was more common in men. HHV-8 DNA samples were sequenced, and all clustered as subtype E. Conclusion: The data support the hypothesis of early acquisition and horizontal transmission, via saliva, of HHV-8 subtype E in Amerindian populations.

ASSUNTO(S)

estudos soroepidemiológicos herpesvírus humano 8 população não indígena reação em cadeia da polimerase non-amerindiam population sequence analysis dna transmissão horizontal de doença disease transmission horizontal população indígena análise de sequência de dna herpesvirus 8human polymerase chain seroepidemiologic studies indigenous populations

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