Induction of beta-lactamase by various beta-lactam antibiotics in Enterobacter cloacae.

AUTOR(ES)

Minami, S

RESUMO

The induction of beta-lactamase in Enterobacter cloacae GN5797 was studied by using 23 beta-lactam antiobiotics, including newly introduced drugs, as inducers. the beta-lactam antibiotics can be classified into three groups on the basis of their inducer activity. Among the tested cephalosporins, cephamycin derivatives such as cefoxitin, cefmetazole, and YM09330 had high inducer activity even at low drug concentrations. On the other hand, cefoperazone, cefsulodin, piperacillin, and apalcillin showed low inducer activity when compared with the other cephalosporins.

Documentos Relacionados

• Characterization of beta-lactamase induction in Enterobacter cloacae.
• Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae.
• Iodometric Assay Method for Beta-Lactamase with Various Beta-Lactam Antibiotics as Substrates
• Beta-Lactamase Production and Resistance to Beta-Lactam Antibiotics in Nocardia
• Outer membrane permeation of beta-lactam antibiotics in Escherichia coli, Proteus mirabilis, and Enterobacter cloacae.