In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe

AUTOR(ES)

Barbosa, Theolis, Arruda, Sérgio, Cavada, Benildo, Grangeiro, Thalles Barbosa, Freitas, Luiz Antônio Rodrigues de, Barral-Netto, Manoel

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2001-07

RESUMO

This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity on lymph node T cells. Additionally, they were able to induce apoptosis and inflammation (frequently associated with high endothelial venule necrosis). The data presented here suggest that the Diocleinae lectins studied can stimulate in vivo T cell activation and apoptosis, as well as present important side effects.

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