Efeito vasodilatador das lectinas de Diocleinae Canavalia gladiata e Canavalia brasiliensis. / Effect of vasodilator Diocleinae lectins Canavalia brasiliensis and Canavalia gladiata.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

09/01/2008

RESUMO

Lectins from the Diocleinae subtribe exhibit high structural similarity. The role of C. brasiliensis lectin (ConBr) in the inflammation have being exploited, but little is known about other lectins belonging to the same genus, such as C. gladiata (CgL). Here, vascular activities of ConBr and CgL were investigated in vivo and in vitro in models of paw edema and contractility of smooth muscle using aorta of Wistar rats. In vivo, the lectins induced paw edema with protein leakage. The edema elicited by CgL and ConBr, the most inflammatory one, lasted 32h, involving prostaglandins, chloride channels and nitric oxide (NO). The lectins association with their specific sugar prevent their effects with different potentials for each lectin, differentiated prevented its effects. In vitro, CgL elicited aorta relaxation with NO, prostacyclin and EDHF participation, while the ConBr effect, only prostaglandins and NO participated. Participation of prostacyclin and EDHF in lectin relaxant responses is inedited. Although the structural similarity of Canavalia lectins, we distinguished different degrees and mechanisms in inflammatory and relaxant responses, which could be attributed to discrete alterations in the lectins primary structures.

ASSUNTO(S)

lectina canavalia inflamação contratilidade efeitos vasculares fisiologia canavalia lectins inflammation contractily vascular effects

ACESSO AO ARTIGO

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