Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype O8 with intestinal mucosa during experimental enteritis.
AUTOR(ES)
Hanski, C
RESUMO
The experimental infection of mice with Yersinia enterocolitica serotype O8 was investigated in a quantitative and histological study. The course of bacterial penetration and spreading was precisely determined by immunohistochemical staining. After oral administration, the bacteria passed the epithelial barrier of the ileum and spread into the lamina propria. By preference they entered Peyer's patches, which were about 1,000 times more heavily colonized than the surrounding epithelium of a comparable surface area. The bacteria proliferated in the follicles, from which they spread into the lamina propria of the villi. At either site most of the bacteria multiplied extracellularly, with only a small percentage observed to be present within the phagocytes. The bacteria did not appear to be able to pass the intact basement membrane; hence, the integrity of the basement membrane is likely to play a role in determining the route of entry and limit of spread of Y. enterocolitica infection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=313160Documentos Relacionados
- Arthritogenicity of genetically manipulated Yersinia enterocolitica serotype O8 for Lewis rats.
- Detection of N-(3-Oxohexanoyl)-l-Homoserine Lactone in Mice Infected with Yersinia enterocolitica Serotype O8
- Role of YadA in arthritogenicity of Yersinia enterocolitica serotype O:8: experimental studies with rats.
- Experimental Yersinia enterocolitica enteritis in rabbits.
- Yersinia enterocolitica: recovery and characterization of two unusual isolates from a case of acute enteritis.
