IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

AUTOR(ES)

Nemeth, Elizabeta

FONTE

American Society for Clinical Investigation

RESUMO

Hypoferremia is a common response to systemic infections or generalized inflammatory disorders. In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin are largely unknown. Our studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL-6–hepcidin axis is responsible for the hypoferremia of inflammation.

Documentos Relacionados

• Corticotropin-releasing hormone regulates IL-6 expression during inflammation
• Hepcidin - the Iron Regulatory Hormone
• Rac1 mediates STAT3 activation by autocrine IL-6
• The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
• Avaliação da expressão de hepcidina e produção de IL-6 por monócitos de indivíduos  idosos