IDO controls the fungal loads and cellular immunity in pulmonary paracoccidiodomycosis developed by susceptible and resistant mice to the fungus. / A IDO controla a carga fúngica e a imunidade celular de camundongos suscetíveis e resistentes à infecção pelo Paracoccidioides brasiliensis.

AUTOR(ES)

Eliseu Frank de Araujo

DATA DE PUBLICAÇÃO

2009

RESUMO

Indoleamine-2, 3-dioxygenase (IDO) and tryptophan catabolism are involved in the control of innate and adaptive immunity against pathogens. We investigated the role of IDO in the pulmonary paracoccidiodomycosis developed by susceptible (B10.A) and resistant (A/J) mice to the fungus. We verified that IDO plays a different effect in innate the immunity of B10.A and A/J mice. Early in the infection, IDO controlled the fungal loads but also induced anergy of CD4+ and CD8+ T cells of B10.A mice. T cell anergy was partially due to the expansion of Treg cells and increased apoptosis of lymphocytes. In resistant mice, IDO controlled the initial fungal loads, but exerted a suppressive effect on T lymphocytes only at week 8. As in B10.A mice IDO was shown to induce Treg cells and apoptosis of lymphocytes in the course of immune response developed by resistant mice. In conclusion our work showed for the first time that IDO play an important role in the fungicidal and immunoregulatory mechanisms developed by susceptible and resistant mice to P. brasiliensis infection.

ASSUNTO(S)

indoleamine 2 linfócitos indolamina 2 3 dioxygenase paracoccidioidomycosis cytokines lymphocytes citocinas 3 dioxigenase paracoccidioidomicose 1-methyl tryptophan macrófagos macrophages 1-metil triptofano

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