Indoleamine 2
Mostrando 1-12 de 75 artigos, teses e dissertações.
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1. Indoleamine-2,3-dioxygenase-related anti-inflammatory effects of 3-aminobenzamide and infliximab in experimental colitis
SUMMARY OBJECTIVE: This study aimed to investigate the presence of indoleamine-2,3-dioxygenase and bacterial translocation after the administration of 3-aminobenzamide and infliximab in the TNBS model of rat colitis. METHODS: The study group was divided into five categories as follows: group 1: (control), group 2: colitis+saline, group 3: colitis+3-aminobe
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Vascular endothelial growth factor-A enhances indoleamine 2,3-dioxygenase expression by dendritic cells and subsequently impacts lymphocyte proliferation
Dendritic cells (DCs) are antigen (Ag)-presenting cells that activate and stimulate effective immune responses by T cells, but can also act as negative regulators of these responses and thus play important roles in immune regulation. Pro-angiogenic vascular endothelial growth factor (VEGF) has been shown to cause defective DC differentiation and maturation.
Mem. Inst. Oswaldo Cruz. Publicado em: 09/10/2013
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3. Participação das células dendríticas plasmocitóides na esclerose múltipla e na encefalomielite autoimune experimental = : Role of plasmacytoid dendritic cells in multiple sclerosis and in experimental autoimmune encephalomyelitis / Role of plasmacytoid dendritic cells in multiple sclerosis and in experimental autoimmune encephalomyelitis
No presente estudo demonstramos a ativação de mecanismos imunosupressores em células dendríticas plasmocitóides (pDCs) e linfócitos B pela ação do agonista de TLR-9, ODN-CpG no modelo de estudo da esclerose múltipla (EM) e na encefalomielite experimental autoimune (EAE). A EAE é o modelo experimental da esclerose múltipla. Nossos resultados demons
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2012
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4. Nível de expressão tumoral da indoleamine 2,3-dioxigenase (IDO) como marcador biológico e preditor de metástase em pacientes com tumor carcinoide típico broncopulmonar / Tumor Expression Level of Indoleamine 2,3 dioxygenase as Biological Marker and Metastasis Predictor in Patients with Typical Bronchopulmonary Carcinoid Tumors
Os tumores carcinoides típicos broncopulmonares (TCTB) são considerados neoplasias bem diferenciadas e as menos agressivas dentro do espectro dos tumores neuroendócrinos. Entretanto, metástases linfonodais e hematogênicas tem sido encontradas em número considerável de casos e não existem, até o momento, estudos relacionados aos mecanismos de escape
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/12/2011
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5. Long-term melatonin treatment reduces ovarian mass and enhances tissue antioxidant defenses during ovulation in the rat
Melatonin regulates the reproductive cycle, energy metabolism and may also act as a potential antioxidant indoleamine. The present study was undertaken to investigate whether long-term melatonin treatment can induce reproductive alterations and if it can protect ovarian tissue against lipid peroxidation during ovulation. Twenty-four adult female Wistar rats,
Braz J Med Biol Res. Publicado em: 2011-03
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6. Metabolismo de triptofano na vigência de choque endotóxico induzido por LPS e hipertriptofanemia / Metabolism of tryptophan in the presence of LPS-induced endotoxic shock and hypertryptofanemia
Triptofano (TRP), um amino ácido essencial, é metabolizado por duas vias principais, a via das quinureninas e a via serotonérgica. Em ambas as vias há a possibilidade de formação de compostos ativos no sistema imune que se caracterizam pelas ações imunossupressoras e indutoras de tolerância. Na via serotonérgica há a formação de serotonina (5-HT
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2010
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7. Susceptibilidade diferencial de células trofoblásticas humanas (BeWo) e cervicais uterinas (HeLa) à infecção por Neospora caninum
Neospora caninum is an obligate intracellular parasite, closely related to Toxoplasma gondii, and considered a major cause of abortion and congenital neosporosis in cattle worldwide. As trophoblast cells act in mechanisms of innate immune defense at fetal-maternal interface, and no data are available about the interaction of this parasite with human trophobl
Publicado em: 2010
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8. IDO controls the fungal loads and cellular immunity in pulmonary paracoccidiodomycosis developed by susceptible and resistant mice to the fungus. / A IDO controla a carga fúngica e a imunidade celular de camundongos suscetíveis e resistentes à infecção pelo Paracoccidioides brasiliensis.
Indoleamine-2, 3-dioxygenase (IDO) and tryptophan catabolism are involved in the control of innate and adaptive immunity against pathogens. We investigated the role of IDO in the pulmonary paracoccidiodomycosis developed by susceptible (B10.A) and resistant (A/J) mice to the fungus. We verified that IDO plays a different effect in innate the immunity of B10.
Publicado em: 2009
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9. Degradation of tryptophan in bovine placenta in normal and cloned pregnancy: is this an evidence of indoleamine 2,3-dioxygenase activity? / Degradação de triptofano na placenta bovina em gestações normais e de clones: evidência da atividade da indoleamina 2,3-dioxigenase?
A tolerância materno-fetaI continua a ser um intrigante enigma imunológico. Algumas teorias têm sido propostas sobre o estabelecimento deste estado, tais como a produção de moléculas solúveis como HLA-G (na gestação humana) por células fetais que inibiriam a atividade de células do sistema imune inato. Além da secreção de hormônios; liberaçã
Publicado em: 2005
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10. Interferon gamma-resistant mutants are defective in the induction of indoleamine 2,3-dioxygenase.
Several mutants of the human cell line ME-180 resistant to the cytotoxic effect of interferon gamma (IFN-gamma) were isolated after mutagenesis with nitrosoguanidine. Two of the mutant lines (ME-IR3b and ME-IR6g) examined had significantly lower induction levels of the L-tryptophan (L-Trp) degradative enzyme indoleamine 2,3-dioxygenase activity in response t
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11. Cytokines Induce Indoleamine 2,3-Dioxygenase Expression in Human Atheroma-Associated Cells: Implications for Persistent Chlamydophila pneumoniae Infection
This study shows that vascular smooth muscle cells express significantly higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (IDO) activity than endothelium or mononuclear cells. Since IDO activity is linked to persistent Chlamydophila pneumoniae infection, our results suggest that smooth muscle cells may be an important reservoir of that
American Society for Microbiology.
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12. Inhibition of interferon-mediated induction of indoleamine 2,3-dioxygenase in mouse lung by inhibitors of prostaglandin biosynthesis.
Inhibitors of fatty acid cyclooxygenase such as indomethacin (0.1 mM), phenylbutazone (0.3 mM), and aspirin (1 mM) were found to suppress almost completely the interferon-mediated induction of indoleamine 2,3-dioxygenase in mouse lung slices. However, phenacetin, an anti-inflammatory agent devoid of cyclooxygenase inhibitory activity, and sodium salicylate,