Hippocampal insulin signaling and neuroprotection mediated by physical exercise in Alzheimer´s Disease

AUTOR(ES)

Kuga, Gabriel Keine, Botezelli, José Diego, Gaspar, Rafael Calais, Gomes, Ricardo José, Pauli, José Rodrigo, Leme, José Alexandre Curiacos de Almeida

FONTE

Motriz: rev. educ. fis.

DATA DE PUBLICAÇÃO

02/05/2017

RESUMO

Abstract Epidemiological studies indicate continuous increases in the prevalence of Alzheimer’s Disease (AD) in the next few decades. The key feature of this disease is hippocampal neurodegeneration. This structure has an important role in learning and memory. Intense research efforts have sought to elucidate neuroprotective mechanisms responsible for hippocampal integrity. Insulin signaling seems to be a very promising pathway for the prevention and treatment of AD. This hormone has been described as a powerful activator of neuronal survival. Recent research showed that reduced insulin sensitivity leads to low-grade inflammation, and both phenomena are closely related to AD genesis. Concomitantly, exercise has been shown to exert anti-inflammatory effects and to promote improvement in insulin signaling in the hippocampus, which supports neuronal survival and constitutes an interesting non-pharmacological alternative for the prevention and treatment of AD. This review examines recent advances in understanding the molecular mechanisms involved in hippocampal neuroprotection mediated by exercise.

Documentos Relacionados

• Alzheimer´s Disease associated with Psychiatric Comorbidities
• Stress and coping in elderlies with Alzheimer´s disease.
• Uma hipotese funcional para (a) praxia no curso da doença de Alzheimer
• Espectroscopia de prótons na doença de Alzheimer e no comprometimento cognitivo sem demência: avaliação de uma amostra da comunidade
• The dementia rating scale (DRS) in the diagnosis of mild cognitive impairment and Alzheimer´s disease