Espectroscopia de prótons na doença de Alzheimer e no comprometimento cognitivo sem demência: avaliação de uma amostra da comunidade / Proton spectroscopy in Alzheimer´s disease and cognitive impairment without dementia: a community study

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

For the description of the proton magnetic resonance spectroscopy (1H-ERM) data in Alzheimer´s disease (AD) and Cognitive Impairment Not Dementia (CIND) in a community set, subjects with AD (n=13), CIND (n=12) and normal control (n=15) were investigated. 1H-ERM was performance with single voxel (8 cm3) placed in temporal, parietal e occipital region and studied metabolites: N-acetylaspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mI). NAA concentration was higher in control subjects than AD and intermediated level in CIND patients; mI was higher in patients with AD and CIND; Cho tended to be higher in AD and CIND. Metabolisms changes are present together the first cognitive deficits as showed by correlation between cognitive tests and 1H-ERM. Spectroscopy can be used in the diagnosis and follow-up of individuals with memory complain in the community set with the possibility of early diagnosis

ASSUNTO(S)

magnetic resonance alzheimer s disease ressonância magnética nuclear spectroscopy cognitive deficits transtornos cognitivos doença de alzheimer espectroscopia

ACESSO AO ARTIGO

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