"Hepatite colestática associada ao vírus da hepatite C pós-transplante hepático: estudo virológico, histopatológico e imuno-histoquímico" / Severe recurrent cholestatic hepatitis after liver transplantation : virological, histological and immuno-histochemical evaluation
AUTOR(ES)
Mário Guimarães Pessôa
DATA DE PUBLICAÇÃO
2004
RESUMO
Following liver transplantation (OLT) HCV-related disease severity is highly variable, with a minority of cases progressing to an extremely severe form of cholestatic hepatitis, in which the pathogenesis is not yet understood. We aim to compare virological, histological and immunohistological changes in patients developing mild and severe post-OLT HCV recurrence. Twelve patients with recurrent HCV infection were studied (6 with severe and 6 with mild disease). Five HCV-infected immunocompetent patients were used as controls. We looked at viral load, quasispecies evolution of HCV, several histological parameters and immuno-reactivity of core antigens at three time-points (pre-OLT, early post-OLT and late post-OLT) as predictors of severity of recurrence post-OLT.
ASSUNTO(S)
replicação viral hepatite c crônica/etiologia virus replication hepatite c crônica/virologia liver transplantation/pathology hepatitis c chronic/etiology hepatite c crônica/fisiopatologia hepatitis c chronic/physiopathology hepatitis c chronic/virology transplante de fígado/patologia
