Heart Rate Variability in Patients with Chronic Obstructive Lung Disease and Nocturnal Oxygen Desaturation / Análise da Variabilidade da Freqüência Cardíaca em Pacientes Portadores de Doença Pulmonar Obstrutiva Crônica e Dessaturação Noturna

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Background: The autonomic nervous system may be disturbed in chronic respiratory failure. Chronic hypoxemia may result in sympathetic activation. There are few studies showing the role of the autonomic nervous system in patients with chronic obstructive lung disease (COPD) and nocturnal oxygen desaturation. Objective: To analyze the sympathetic and parasympathetic components of heart rate variability (HRV) in patients with COPD and nocturnal oxygen desaturation. Methods: Twenty-six patients with COPD were submitted to overnight polysomnography with 24-hour Holter to assess HRV. Time domain (TD) and frequency domain (FD) techniques were carefully performed. HRV was measured in the awake state and during sleep stages. Gasometric analysis and the six- minute walk test were performed. Results: There was significant correlation (p <0,05) between the T90 and the six-minute walk test and with the components SDNN (TD) and LF, LF/HF (FD). The average heart rate during 24h-Holter had significant correlation (p <0,02) with the SDNN. The paO2 during the awake state had slight correlation (p = 0,06) with the SDNN (TD). Conclusion: Some temporal and spectral components of the HRV are altered in COPD patients, and the nocturnal oxygen desaturation can plays an important role in the autonomic nervous system disturb

ASSUNTO(S)

chronic obstructive lung disease autonomic nervous system doença pulmonar obstrutiva crônica nocturnal oxygen desaturation cardiologia heart rate variability dessaturação noturna variabilidade da freqüência cardíaca sistema nervoso autônomo

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