Gene-dosage effects in Down syndrome and trisomic mouse models
AUTOR(ES)
Gardiner, Katheleen
FONTE
BioMed Central
RESUMO
Several groups have confirmed that the abnormalities found in Down syndrome (trisomy 21) result from increased expression of genes on chromosome 21 because of their higher gene dosage.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=545589Documentos Relacionados
- Drosophila locus with gene-dosage effects on rhodopsin
- Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance
- On the Mode of Gene-Dosage Compensation in Drosophila
- Influence of homoeologous chromosomes on gene-dosage effects in allohexaploid wheat (Triticum aestivum L.).
- Gene-dosage compensation of endosperm proteins in hexaploid wheat Triticum aestivum