Drosophila locus with gene-dosage effects on rhodopsin

AUTOR(ES)

Scavarda, N. J.

RESUMO

Mutations that decrease the amplitude of the prolonged depolarizing afterpotential (PDA) in Drosophila melanogaster have been shown to have reduced rhodopsin content in the rhabdomeres of photoreceptor cells. In the present study, a genetic analysis of a class of third chromosome PDA-defective mutants localized the ninaE locus to the salivary band region 92A-B. In flies with only one copy of this region instead of the normal two copies, and in ninaE heterozygotes, the rhodopsin content of the major class of photoreceptors is reduced. Three doses of this region increase the rhodopsin content of these photoreceptors. These characteristics of the ninaE locus are expected of the structural gene encoding the major species of opsin in the Drosophila compound eye.

Documentos Relacionados

• On the Mode of Gene-Dosage Compensation in Drosophila
• Gene-dosage effects in Down syndrome and trisomic mouse models
• Influence of homoeologous chromosomes on gene-dosage effects in allohexaploid wheat (Triticum aestivum L.).
• Gene-dosage compensation of endosperm proteins in hexaploid wheat Triticum aestivum
• Metabolic Studies in Familial Hypercholesterolemia: EVIDENCE FOR A GENE-DOSAGE EFFECT IN VIVO