FreqÃÃncia e fatores de risco da DoenÃa HepÃtica Gordurosa NÃo AlcoÃlica em pacientes com Diabetes Mellitus tipo 2 atendidos no HC-UFPE

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Proposal: In the Western world, where the lifestyle has contributed to an increase in obesity, dyslipidemia and diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD) has already become the most common chronic liver disease, despite studies about it having only begun in the 1980s. NAFLD is closely linked to cases of insulin resistance (IR), and when linked with Type 2 Diabetes (T2D) its prevalence is between 35 to 75% of patients. These patients often suffer from a worsening of the disease, and recent studies have shown this link to contribute to cardiovascular risk and mortality. Objectives: Identify the frequency of NAFLD in T2D patients, describing clinical and laboratorial characteristics by means of the identification of the risk factors. Methods: First of all the subject was reviewed, through articles published in current scientific journals on Medline, Pubmed, Lilacs and Google Scholar, which led to the Literature Review. After this a group of 78 DT2 patients were studied between July and December 2007. This group was made up of male and female outpatients of the Hospital das Clinicas â UFPE, aged between 33 to 77 years old. This group did not include patients using hepatotoxic drugs, excessive alcohol drinkers and those with positive markers for hepatitis B or C, or other hepatic diseases. The patients were examined, medical histories were obtained and blood samples were taken to determine blood glucose level, lipid profile, hepatic enzymes, homeostasis model assessment (HOMA) and Tumor Necrosis Factor alpha (TNF-α) . The NAFLD diagnosis was made by ultrasound. The following variables were also evaluated: weight, height, abdominal circumference, body mass index (BMI), Metabolic Syndrome (MS) and High Blood Pressure (HBP). The data was subjected to statistical analysis, which led to the original article. Results: The first article described a review of the topic âNon-Alcoholic Fatty Liver Disease and Type 2 Diabetesâ. The second article, the original, âFrequency and Risk Factors of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes Patientsâ identified a frequency of hepatic steatosis (HS) in 42.3% of the patients. Furthermore, the variables: BMI, abdominal obesity, insulin dose, AST, ALT, γGT, uric acid, triglycerides, HBP, MS, HOMA and TNF-α were statistically observed to be considerably different in the group with steatosis. Conclusion: NAFLD is frequent in T2D patients, who show HBP, MS, BMI, abdominal obesity, hepatic enzymes, uric acid, TNF-α and HOMA, higher in the patients with HS than in those without HS

ASSUNTO(S)

ciencias da saude resistÃncia insulÃnica insulin resistance type 2 diabetes diabetes tipo 2 homa tnf-α esteatose hepÃtica homa hepatic steatosis tnf-α

ACESSO AO ARTIGO

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