Fatores que interferem na reação imune cruzada entre phytomonas serpens e trypanosoma cruzi

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

The immune cross-reaction between Trypanosoma cruzi, the etiological agent of Chagas´ disease and Phytomonas serpens, a trypanosomatid parasite of tomatoes can be used for diagnostic and protective purposes in experimental murine models. Phytomonas serpens is available in various strains, cultivated from infected tomato fruits at various times and places, all with strong surface immune cross reactions with human chagas´ disease sera . Two of them, 9T strain, reference species of P. serpens, and 15T, utilized for immunological studies, were compared in mice immunization experiments and both reduced significantly the parasitemia of T. cruzi lethal challenge but only 15T strain prolonged survival. With strains BALB/c and Swiss of mice, genetically sensible to T. cruzi infection, a reduction of parasitemia and a small delay of survival is obtained with the immunization with 15T strain of P. serpens, while with the mice strain C57BL/6, genetically resistant to T. cruzi, not only parasitemia practically disappear as the survival was obtained for months. These results corroborate the participation of genetic aspects of the parasite and of the host. Various molecules detected by Western Blot was not recognized by all human sera from Chagas´ disease and Leishmaniasis patients as well normal sera, indicating variability in the immune recognition among the human individuals. These data denote that the immune cross-reaction is a complex task, with results depending on host and parasite characteristics.

ASSUNTO(S)

immune system sistema imune imunologia immunological system immunology

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