Facile and Efficient Synthesis of [18F]Fluoromisonidazole Using Novel 2-Nitroimidazole Derivatives

AUTOR(ES)

Kwon, Young-Do, Jung, Yongju, Lim, Seok Tae, Sohn, Myung-Hee, Kim, Hee-Kwon

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2016-06

RESUMO

[18F]Fluoromisonidazole ([18F]FMISO) is a hypoxia imaging marker utilized in positron emission tomography. Novel FMISO precursors were prepared from a commercially available material, and several reaction factors that affect synthesis of [18F]FMISO were examined to achieve a higher fluorination yield. [18F]FMISO was obtained from radiosynthesis, followed by the hydrolysis of protecting groups with HCl. New 2-nitroimidazole precursor showed a higher [18F]fluorination and a higher synthetic yield. This result provided alternative guidelines for the preparation of hypoxia imaging marker.

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