"Expressão das proteínas Fas e Bcl-2 em células mononucleares de crianças e adolescentes com lúpus eritematoso sistêmico" / Expression of Fas and Bcl-2 proteins on mononuclear cells from children and adolescents with systemic lupus erythematosus

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

In order to verify the expression of Fas and Bcl-2 proteins on lymphocytes and their relationship with disease activity 38 patients with juvenile-onset systemic lupus erythematosus and 25 healthy controls were studied. The measurements showed that percentages of lymphocytes T CD3+ and CD8+ and B lymphocytes positively stained for Fas antigen and mean fluorescence intensity of Bcl-2 on CD3+, CD4+ and CD8+ T cells from lupus patients were significantly increased compared to healthy controls. Lupus patients with active disease presented percentages of lymphocytes B positive for Fas antigen significantly higher compared to patients with inactive disease and healthy controls and there was a statistically significant direct correlation between these percentages and SLEDAI score (p=0.02, r=0.38).

ASSUNTO(S)

Índice de gravidade de doenÇa adolescente lupus erythematosus systemic/physiopathology citometria de fluxo auto-imunidade child proto-oncogene proteins c-bcl-2 antÍgenos cd95 apoptosis apoptose adolescent crianÇa severity of illness index flow cytometry antigens cd95 proteÍnas proto-oncogÊnicas c-bcl-2 lÚpus eritematoso sistÊmico/fisiopatologia autoimmunity

ACESSO AO ARTIGO

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