Evaluation of the extended intercellular space of the esophagic mucous membrane before and after infusion of chloridric acid : marker of disease of gastroesophagic reflux / "Avaliação do espaço intercelular dilatado da mucosa esofágica antes e após infunsão de ácido clorídrico: marcador da doença do refluxo gastroesofágico (DRGE)"

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

The purpose was to prove the presence of extended intercellular space of the esophagic epithelium after chloridric acid infusion (HCI) to 0,1N comparing to the physiologic serum infusion (PS) in patients without typical symptoms of DGER with normal esophagic mucous membrane and compare them to ones with typical symptoms and erosive esophagitis. 60 patients were interviewed and took the high digestive endoscopy; 29 were included in the research, among them 18 with normal esophagus (9 were infused PS, and 9 HCI) and 11 with erosive esophagitis (6 were infused PS and 5 HCI); 4 biopsies of esophagic mucous membrane were made (2 before and 2 after infusions). It was not found any statistically meaningful difference in intercellular space of esophagic mucous membrane in patients with or without erosive esophagitis with chloridric acid or physiologic serum, and thus it is not a DGER

ASSUNTO(S)

diagnosis mucous membrane Ácido clorídrico membrana mucosa gastroesophageal reflux/pathology microscopia eletrônica refluxo gastroesofágico/patologia epitélio espaço intercelular diagnóstico microscopy electron marcadores biológicos epithelium biological markers extracellular space hydrochloric acid

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