Evaluation of the compound of granulated Ricinus and synthetic hydroxyapatite on the osseointegration in rabbits: histological study / Avaliação do composto ósseo de Ricinus granulado e hidroxiapatita sintética na osteointegração em coelhos: estudo histológico

AUTOR(ES)

Christiano Pavan Mateus

DATA DE PUBLICAÇÃO

2010

RESUMO

With the growing commitment of human and veterinary medicine in the search for biomaterials osseointegration, the histological study is present in the interpretation and presentation of results of histomorphologic interactions of materials implanted with bone tissue, providing a speed of bone formation. The proposal was evaluated by histological study the bioactivity of the compound of granulated Ricinus and synthetic hydroxyapatite implanted in rabbit iliac bone, allowing a better understanding of the interactions of bone-implant interface, as compared with histopathologic results, and interpreted and presented by qualitative descriptive analysis. We used 30 female rabbits, Oryctolagus cuniculus, group - Botucatu, adulthood in 90 days, weighing between 2.55 and 3.1 kilograms divided into 3 groups of 10 animals (G1, G2 and G3) and that the length after surgery was 45 days with G1, G2 in 70 days and G3 with 120 days. Each animal received 3 bone defects in the pelvic bone, two of which were completed by biomaterials: synthetic hydroxyapatite and compound of granulated Ricinus and the third for control. After euthanasia, the iliac bone was removed, identified and subjected to histological procedures. It was concluded by the increasing histological modification of the initial structure for the deposition of new bone formation, towering giant cells of foreign body (in some cases), fibroblasts and abundant presence of connective tissue without bone differentiation. And the materials were considered as biocompatible and biologically active.

ASSUNTO(S)

implant implante synthetic hydroxyapatite histologia histology osteointegração compound of granulated ricinus hidroxiapatita sintética composto de ricinus granulado osseointegration

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