Estudo quÃmico, fÃsico-quÃmico e farmacolÃgico dos carboidratos presentes no fitoterÃpico ( Xarope MelxiÂ)

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Melxi syrup is a phytotherapic produced and commercialized by Hebron Laboratory. It is basically composed by honey and pineapple pulp (Ananas comosus) which is used as expectorant and mucolytic agent. The honey possesses an excellent nutritional quality (vitamins, minerals, high energetic value) and medical properties (antioxidant and antiseptic activities). Monosaccharides constitute the major part among the sugars found in the honey, varying from 85% and 90% of its composition. Pineapple is not a caloric fruit however it contains high percentage of vitamins A, B and C, and also carbohydrates, mineral salts and fibres. It is the source of the enzyme bromelain, which is an excellent auxiliary for digestion. The objective of this work was analyse the carbohydrates present in the Melxi. The phytotherapic was treated with acetone for delipidation and subjected to proteolise by using the enzyme papain. The carbohydrates extracted was chemically and physicochemically analysed by spectrophotometry, paper chromatography, thin layer chromatography and high performance liquid chromatography (HPLC). Samples after proteolise presented a protein contamination lower than 10μg/mL. The presence of flavonoids was not identified in the carbohydrate extracted. The content of neutral sugars was around 5.4 mg/mL. Paper and thin layer chromatografies revealed the following carbohydrates: sucrose, sorbitol, fructose, maltose, melezitose and glucose. In the HPLC chromatograms were observed four peaks corresponding to melezitose, sucrose, glucose and fructose. Melxi syrup samples showed antimicrobial activity by inhibiting the Escherichia coli, Streptococcus sp and Pseudomonas aeruginosa growth. In the anti-inflamatory activity it was observed 57.72% of reduction inflammation in the mouses which was higher than by using AAS as standard. Then It can conclude that Melxi contains important carbohydrates with pharmacological activities

ASSUNTO(S)

estudos farmacolÃgicos bioquimica carboidratos fitoterÃpicos

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