Estudo morfoquantitativo dos rins de camundongos (Mus musculus) tratados com extrato aquoso de Dioclea grandiflora Mart. ex. Benth. (Fabaceae)

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

The utilization natural plants for medical treatment by population is a common practice since ancient times, where organic diseases were treated. In scientific literature, researches about histology and kidney morphometry of animals treated with medical plants are still few. The purpose of this study was evaluate and quantify morphologic alterations in mice kidneys treated with the pulp of the stem known as Dioclea grandiflora and its peel, a medicine plant spread along semi wilderness and plateau regions in Northeastern Brazil, utilized by the low income population for preparing infusions on prostatic and renal diseases. Sixteen swiss albine mice have been divided (Mus musculus) at the age of 45 and 60 days, with an average weight of about 22 to 32g in two groups of eight animals each>the group (C) was given a salt solution 0,9% of NaCl and the group (EX) was given the Dioclea grandiflora stem peel pulp dissolved in physiological serum during seven days via intraperitoneal. The peel pulp dosage for the treatment explained above has been 62mg/kg according to the DL 50 reckoning. After the sacrifice of the animals, kidneys have been selected post-laterally and subjected to histological routine. In this histological study it was noticed significant structural differences among groups analized as: glomerular hiperemy, tubular degeneration, glomerular tuft disorganization and cell proliferation in the mesangial matrix. In the morphometrical analysis it was observed renal corpuscules area reductions glomerule and capsular space. The results enable to suggest histological and morphometrical alterations are due to the magnitude of plantâs toxical action on renal components. Therefore the research shows the importance of studies involving medicine plants and their possible toxical effects

ASSUNTO(S)

kidneys anatomia patologica e patologia clinica morfometria morphometry dioclea grandiflora ratos morphology mice dioclea grandiflora morfologia

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