Estudo da pele humana fotoenvelhecida após tratamento com terapia fotodinâmica associada ao ácido 5-delta-aminolevulínico tópíco: avaliação imunoistoquímica, do colágeno e do tecido elástico / Study of photo aged human skin after photodynamic therapy treatment with topic 5 delta aminolevulinic acid: immunohistochemical, colagenous and elastic fibre analysis.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

PDT is nowadays considered one of the therapies for photo-aging, since it gives a satisfactory response for both, aesthetic result as well as treating and preventing pre-malignous lesions that are a frequent outcome of photo-aged skin. The selective destruction of target tissue occurs through a chemical reaction, by using a photosensitizing agent exposed to a certain light with a wave length which, in the presence of oxygen, produces singlet oxygen responsible for the citotoxidity of the proliferative cells and consequent cellular death. Thirteen pacients with clinical photo-aging have been studied, submitted to three sections of topic ALA-PDT associated with red light (630nm) at fortnight?s intervals.After 21 days of the last treatment, 12 patients showed improved photo-aging, specially regarding skin colour and texture, whitening of the solar melanosis lesions, regression of actinic cheratosis and improvement of flacidity. There also occured an increase of colagenous and elastic fibre tissue in the picrosirius and Weigert-oxona methods respectively.. Regarding the modulation of the immune system, there was a decrease of the lymphocytes CD4 and CD8 population, an increase of interleucin-4 in the epidermis and in the dermis, decrease of TNF-α in the epidermis and increase in the dermis. The Langerhans cells poulation and the INF-γ did not present alterations. The ALA-PDT associated to red light was effective for the treatment of clinical photo-aging, for colagenous and elastic fibres increase and in the imune system modulation.

ASSUNTO(S)

Ácido 5 delta aminolevulínico hystomorphometrial imunoistoquimica elastic fibre imunohistochemistry fibra elástica histomorfometria 5 delta aminolevulinic acid colagenous photodynamic therapy imune system colágeno terapia fotodinâmica sistema imune. skin aging envelhecimento da pele

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