Estudo comparativo da angiogenese, expressão de p53 e indice proliferativo em lesões ceratoacantoma-similes, com enfase na regressão clinica / Comparative study of angiogenesis, p53 expression and proliferation index in keratoacanthomas and squamous cell carcinomas

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

Keratoacanthoma (KA) is a cutaneous tumor of great interest because of its unique characteristics and controversial relationship to squamous cell carcinoma (SCC). We hypothesized that differences in microvessel density (MVD), p53 expression and proliferation index could be related to the distinct behavior between KAs and SCCs and that their assessment could help distinguish between these entities. Immunohistochemical staining was performed with markers for vessels (CD34 and CD105), p53 oncoprotein and cell proliferation (Ki67). Microvessel densities and p53 and Ki67 quantifications were calculated using computer-assisted image analysis. There were no significant differences between KAs and SCCs regarding neither p53 expression nor microvessel density. The Ki67 proliferation index was significantly higher in SCCs, but there was considerable overlap between the groups. We found an indirect correlation between CD105-MVD and the density of pre-existing vessels in both tumors. For KAs we also observed a positive correlation between CD105-MVD and Ki67 index whereas SCCs demonstrated significant positive correlations between tumor size and age and tumor size and p53. MVD was not a useful tool in the distinction between KAs and SCCs. However, despite the fact that these neoplasms have more similarities than differences, there are probably distinct mechanisms involved in their pathogenesis

ASSUNTO(S)

angiogenese keratoacanthoma squamous cell carcinoma carcinoma de celulas escamosas ceratoacantoma celulas - proliferação cell proliferation angiogenesis

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