Estrogen receptor 1 gene polymorphisms and coronary artery disease in the brazilian population
AUTOR(ES)
Almeida, Silvana de
DATA DE PUBLICAÇÃO
2010
RESUMO
We examined the association of three established single nucleotide polymorphisms, IVS1-397T>C, IVS1-351A>G, and +261G>C, in the ESR1 gene with the prevalence and severity of coronary atherosclerosis in a southern Brazilian population of European ancestry. Three hundred and forty-one subjects (127 women and 214 men) with coronary artery disease (CAD) were classified as having significant disease (CAD+ patient group) when they showed 60% or more luminal stenosis in at least one coronary artery or major branch segment at angiography; patients with 10% or less luminal stenosis were considered to have minimal CAD (CAD- patient group). The control sample consisted of 142 subjects (79 women and 63 men) without significant disease, in whom coronary angiography to rule out the presence of asymptomatic CAD was not performed.
ASSUNTO(S)
esr1 polymorphisms polimorfismo coronary artery disease estrogenos estrogen cardiopatias hormonal status
ACESSO AO ARTIGO
http://hdl.handle.net/10183/21196Documentos Relacionados
- Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population
- Matrix metalloproteinase gene polymorphisms in patients with coronary artery disease
- Matrix metalloproteinase gene polymorphisms in patients with coronary artery disease
- A lack of association between adiponectin polymorphisms and coronary artery disease in a Chinese population
- Associations between CD36 gene polymorphisms and susceptibility to coronary artery heart disease
