Estimation of the fluoxetine application with recovery of ciatic nerve in wistar rat / AvaliaÃÃo do uso da fluoxetina na reparaÃÃo do nervo ciÃtico em ratos wistar

AUTOR(ES)

Michelly CauÃs de Queiroz Gatis

DATA DE PUBLICAÇÃO

2006

RESUMO

Objectives: the present study evaluated the sciatic nerve lesions recovery in rats after crush lesion and the use of floxetine. Methods: the sample was performed with forty male Wistar rats, weighing 300-400 g. Animals were housed in a central animal care facility with 12-h light cycles and given chow and water ad libitum. Following anesthetic induction, the sciatic nerve was exposed and crushed with a Pean pincer. The animals were distributed in control and experimental groups. The experimental groups were divided in three other groups with 10 animals and treated with subcutaneous fluoxetine 5mg/kg/day, 10mg/kg/day or 20 mg/kg/day for 35 days. The control group received saline solution (0.9%), also subcutaneous administration for 35 days. The motor function was analyzed with sciatic functional index (SFI) and sciatic static index (SSI) were calculated from inked footprints. Retraction time (RT) was computed from the time of retraction of the leg from nociceptive reflex, in order to evaluate the sensitive pain fibers regeneration. These data were obtained in 1st, 7th, 14th, 21st, 28th and 35th days. Results: Significant difference were observed, retraction time was higher in 5mg/kg/day doses group after 35 days. In SFI calculations was observed that 10mg/kg/day and 20 mg/kg/day groups presented higher functional deficits than control groups only in 14th day after sciatic lesion. SSI calculations demonstrated deficit in motor functional recovery only in the 14th day in the 10mg/kg/day. Conclusions: Fluoxetine promoted deficit in the motor functional recovery only in the 14th day of treatment with doses of 10 and 20mg/kg/day in wistar rats. In lower doses was observed deficit in nociceptive reflex of pain in the 35th day of treatment with fluoxetine

ASSUNTO(S)

wight sciatic nerve dor nerve regeneration pain regeneraÃÃo nervosa fluoxetina fluoxetine peso motor nervo ciÃtico motor ciÃncias da saÃde

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