Esteato-hepatite não alcoólica (ENA) em camundongos obesos (ob/ob): avaliação do efeito citoprotetor do Yo Jyo Hen Shi Ko (YHK) / YO JYO HEN SHI KO, a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine/choline deficient diet
AUTOR(ES)
Vicência Mara Rodrigues de Lima
DATA DE PUBLICAÇÃO
2007
RESUMO
Background: Oxidative stress plays a role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Yo Jyo Hen Shi Ko (YHK) is a complex compound purported to reduce reactive oxygen species (ROS) by blocking the propagation of radical-induced reactions. Aim: The aim of this study was to evaluate the role of the effect of YHK in experimental NASH. Methods: NASH was induced in male ob/ob mice by a high-fat (H) diet or methionine/choline deficient (MCD) diet for 4 weeks. YHK-treated animals received YHK solution orally (20 mg/kg/day) in both experimental diets (n = 5; each group) while control animals received only vehicle. Results: The MCD and H groups developed moderate diffuse macrosteatosis, hepatocellular ballooning, and a diffuse inflammatory infiltrate. With the addition of YHK, there was a marked reduction in macrosteatosis in both groups. This was associated with decreased lipoperoxide and reduced glutathione (GSH) concentrations as well as reduced serum aminotransferases and improved histological markers of inflammation. These changes were also associated with weight loss in the MCD+YHK group and diminished weight gain in the H+YHK group. Conclusion: YHK therapy blunts the development of macrosteatosis in these models of NASH and significantly reduces markers of oxidative stress. YHK also diminishes weight gain in this obesity prone model. Our findings warrant further study on the mechanisms involved with these effects.
ASSUNTO(S)
fígado gorduroso obesity cirrose hepática obesidade liver cirrhosis oxidative stress fatty liver estresse oxidativo
Documentos Relacionados
- Evaluation of Yo Jyo Hen Shi Ko (YHK) in hepatic lipid metabolism in experimental steatohepatitis
- Y4 receptor knockout rescues fertility in ob/ob mice
- Análise proteômica comparativa de miócito cardíaco de comundongos ob/ob e ob/OB : novas estratégias no entendimento dos efeitos do exercício físico sobre a obesidade
- Recombinant ob protein reduces feeding and body weight in the ob/ob mouse.
- Esteato-hepatite relacionada ao vírus da hepatite C: perfil clínico-histológico