Estado nutricional e ácidos graxos plasmáticos de pacientes com câncer de colo uterino

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Objective: The aim of this study was to evaluate the nutritional status and plasma phospholipids fatty acid composition in cervix cancer patients compared to healthy control women and the changes in these parameters during radiotherapy. Methods: The study was conducted with 29 cervix cancer patients and 25 healthy women (control group). The nutritional status was determined by anthropometry. The food intake was evaluated with a food frequency and 24 hours food intake questionaires. The plasma lipids were extracted by Folchs method, the phospholipids were separated by thin layer chromatography and the fatty acids were identified by gas chromatography. Results: The body mass index of patients and control group were similar, however, patients lost weight in relation to their past six months weight. The patients continued losing weight during the radiotherapy. In consequence, malnutrition increased and two months after the treatment, although weight gain occurred, it was insufficient to recover their previous weight. Compared to control group, patients showed increased plasma concentrations of 18:0 (p<0.001) and 24:0 (p<0.001) and decreased 16:0 (p=0.001) and LA (p=0.02) and a trend towards lowered 20:5n-3 (p=0.06). The radiotherapy decreased plasma phospholipid concentration of 24:0 (p<0.001), 22:2 (n-6) (p<0.05) and 20:5n-3 (p<0.001). Conclusion: The differences observed in body weight and plasma phospholipids fatty acids composition before treatment may be related to intake or to the effects of the disease. Radiotherapy seems to decrease plasma 20:5n-3 by a yet unknown mechanism.

ASSUNTO(S)

nutricao nutritional status pufa n-3 radioterapia fosfolipídios pufa n-3 radiotherapy plasma phospholipids nutrição câncer cervical cervix cancer

ACESSO AO ARTIGO

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