Esplenomegalias em cães: estudo retrospectivo e análise imunohistoquímica do Fator de Crescimento Endotelial Vascular (VEGF) / Splenomegaly in dogs: retrospective study and immunohistochemical analysis of Vascular Endothelial Growth Factor (VEGF)

AUTOR(ES)

Andressa Gianotti Campos Nitrini

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

18/06/2010

RESUMO

New blood vessel formation is a fundamental event in the process of tumor growth and metastatic dissemination, being the vascular endothelial growth factor (VEGF) one of the key regulators of this process. The aim of this study was evaluate the VEGF immunohistochemical expression in splenic hemangiosarcomas and hemangiomas, and review the prevalence of canine splenic disorders through retrospective analysis of histological diagnosis after splenectomy. The results were confronted with laboratory findings, clinical signs and presence of cardiac arrhythmia and hemoperitoneum. A hundred nine dogs were included in the retrospective study at Veterinary Hospital of School of Veterinary Medicine, University of Sao Paulo, between 2002 and 2009. The average age was 10 year ± 3, without sexual predilection. Mix breeds were the most frequent, and average weigh was 22kg ± 13. Overall, 52% (57/109) of dogs were splenectomized for nonneoplastic disease, although 48% (52/109) were splenectomized for neoplasia. Among these dogs the most common diagnosis was hemangiossarcoma (28 dogs, 54%). Frequently clinical signs included anorexia, lethargy and vomiting. Dogs with malignant neoplasia had significantly lower red blood cells counts and packed cell volume compared with values for dogs with benign masses. Similarly, hemoperitoneum secondary to splenic rupture had a significant correlation with malignant tumor. Cardiac arrhythmia was not useful in differentiating dogs with splenomegaly. Expression of vascular endothelial growth factor was made by immunohistochemical analyses in 23 hemangiosarcomas and 7 hemangiomas being significantly higher in malignant tumor. These data suggest that VEGF expression may contribute to malignant proliferation of hemangiossarcoma.

ASSUNTO(S)

baço cães dogs fator de crescimento endotelial vascular immunohistochemical imunohistoquímica spleen vascular endothelial growth factor vegf vegf

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