Efficient Synthesis of Rhodanine-Based Amides via Passerini Reaction using Tetramethylguanidine-Functionalized Silica Nanoparticles as Reusable Catalyst

AUTOR(ES)

Baharfar, Robabeh, Azimi, Razieh, Barzegar, Sheida, Mohseni, Mojtaba

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2015-07

RESUMO

Novel rhodanine-based amide derivatives were prepared in good yields via Passerini reaction of rhodanine-N-acetic acid with aromatic aldehydes and tert-butyl isocyanide in the presence of tetramethylguanidine immobilized on silica nanoparticles (TMG-SiO₂ NPs) as a heterogeneous base catalyst. The synthesized compounds were evaluated for their antibacterial effects against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis.

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