Efficacy of Voriconazole in a Guinea Pig Model of Disseminated Invasive Aspergillosis

AUTOR(ES)

Kirkpatrick, William R.

FONTE

American Society for Microbiology

RESUMO

Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericin B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

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