Efficacy of SCH56592 in a Rabbit Model of Invasive Aspergillosis

AUTOR(ES)

Kirkpatrick, William R.

FONTE

American Society for Microbiology

RESUMO

SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.

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