Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model
AUTOR(ES)
Melo, Nayanna de Oliveira Ramos, Juanes, Camila de Carvalho, Alves, Mayara Freire de Alencar, Silva, Emiliano Tiago Melo, Jamacaru, Francisco Vagnaldo Fechine, Lemos, Telma Leda Gomes de, Dornelas, Conceição Aparecida
FONTE
Acta Cir. Bras.
DATA DE PUBLICAÇÃO
2018-05
RESUMO
Abstract Purpose: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. Methods: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV: red propolis 100 mg/kg, GII and GVI: celecoxib 20 mg/kg, GIII and GVII: 1% gum arabic 5 mL/kg, GIV and GVIII: distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E). Results: In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001). Conclusion: Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.
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