Efeitos das ondas de choque no crescimento e na função renal : estudo experimental em ratos




The long-term effects of extracorporeal shock wave lithotripsy (E.S.W.L) on children treated by renal calculi are unclear. To study the chronic bio-effects of this treatment on immature animaIs we evaluated 34 Wistar white rats. At 40 days of age, with an average weight of 166 g the animaIs were divided into 3 groups: control group - 9 rats received no shock waves; group 1 - 10 rats received 1000 shock waves at 16.0 Kv and group 2 - 15 animals received 1000 shock waves at 17.2 Kv. Six months later, at maturity (7 months 10 days of age), the following parameters were measured: body weight, renal weight, blood sodium, potassium, lithium and creatinine, fractional sodium, potassium and lithium excretion and clearance of lithium and creatinine. The kidneys were grossly and histologically studied. We found no significant change in over-all animal and renal growth in the post-E.S.W.L. groups versus the control group. However, there were significant changes in the renal function, mainly in group 2. The animaIs of this group presented significant increased in blood lithium and potassium besides significant decreased in the fractional potassium excretion compared to control group. Furthermore, the 1000 x 17.2 Kv group showed permanent histological renal changes, including red cells in the Bowman s capsula and glomerular congestion. We conclude that E.S.W.L. does not affect over-all animal either renal growth. By the other hand, it can cause significant changes in renal function and permanent histological damage


aparelho urinario ondas de choque

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