Efeitos da l-alanil-glutamina na isquemia e reperfusÃo em cÃrebro de ratos wistar / Effects of l-alanyl-glutamine in ischemia and reperfusion in the brain of Wistar rats

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

09/09/2009

RESUMO

The aim of this study was to investigate the effects of L-alanyl-glutamine (Ala-Gln) in ischemia and reperfusion in rat brain. We used 48 male rats, Wistar, with a mean age of 62 days and average weight of 276.38 g, divided into four groups: Sham 30 minutes ischemia, 90 minutes and Sham Ischemia / Reperfusion. We used a model of experimental global cerebral ischemia with occlusion of bilateral common carotid artery and administration of saline or Ala-Gln. The results of this study showed a statistically significant increase in the percentage of necrotic area of the ischemia group (13.24 Â 8.82) than in group Sham 30 minutes (0.12 Â 0.20, p= 0.01). The same occurred in relation to the area of necrosis in ischemia-reperfusion group (13.30 Â 9.91) compared to Sham 90 minutes (0.70 Â 1.35, p= 0.01). These results demonstrate the effectiveness of the model Ischemia and Ischemia / Reperfusion brain used. There was no significant change in the percentage of necrotic area between Salina ischemia groups (13.24 Â 8.82) and ischemia Ala-Gln (15.35 Â 6.80, p= 0.34). The average percentage of ischemic area of group Ischemia / Reperfusion Ala-Gln (4.65 Â 1.44) was significantly lower than that in group Ischemia / Reperfusion Salina (13.30 Â 9.91, p= 0.03). The prior administration of Ala-Gln in rats subjected to ischemia / reperfusion did not cause reduction in the percentage of necrosis in ischemic injury. Moreover, this dipeptide reduced the percentage of necrosis in the cerebral injury cerebral ischemia / reperfusion.

ASSUNTO(S)

fisioterapia e terapia ocupacional isquemia encefÃlica reperfusÃo cerebral ischemia reperfusion. l-alanyl-glutamine necrosis glutamina

ACESSO AO ARTIGO

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