AlteraÃÃes metabolicas na isquemia e reperfusao da medula espinhal em ratos pre-tratados com l-alanil-glutamina / Metabolic alterations in isquemia and reperfusÃo of the spinal marrow in rats prÃ-tratados with l-alanil-glutamina
AUTOR(ES)
Sonia Elizabeth Lopez Carrillo
FONTE
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia
DATA DE PUBLICAÇÃO
18/12/2003
RESUMO
A study has been conducted to investigate the effects of L-alanyl-glutamine (L-Ala-Gln) upon blood and tissue (spinal cord) concentrations of glucose, pyruvate, lactate and ATP in rats subjected to spinal cord ischemia/reperfusion. Seventy-two male Wistar rats distributed in 2 equal groups received either saline 2.0 ml or 20% solution of L-Ala-Gln (0.75g/Kg). Thirty minutes later rats of each group were randomized in two subgroups (n=18) and subjected to surgical trauma (G1) or to surgical trauma and infradiafragmatic aortic clamping for 30 minutes (G2), followed by 10 or 20 minutes of reperfusion. L-Ala-Gln treated rats were subjected to the same procedures (G3 and G4, respectively). Arterial blood and spinal cord samples were collected and the end of ischemia and 10/20 minutes later. Metabolites were submitted to enzymatic analyses. Results were expressed as Mean  S.E.M. Studentâs âtâ and Mann-Whitney tests were utilized for statistical analyses. P<0.05 was accepted as significant. Blood and spinal cord glucose and lactate were not different in G1 and G2 rats. However, spinal cord pyruvate concentrations decreased significantly after 20 minutes of reperfusion in L-Ala-Gln treated rats (G3) compared with G1. ATP concentrations decreased significantly in G4 rats, reflecting an increased utilization for energy production. Lactate concentrations were also increased during reperfusion in ischemic L-Ala-Gln treated rats (G4) possibly due to an increased turnover of pyruvate to lactate. It is concluded that the model utilized in this study did not induce an important spinal cord ischemia. Increased blood and spinal cord lactate concentrations could be related to enhanced glycolysis possibly secondary to increased glutamate availability leading to malate-aspartate shuttle activation
ASSUNTO(S)
lesÃo de reperfusÃo isquemia medula espinhal cirurgia experimental l-alanyl-glutamine metabolites reperfusion injury ischemia spinal cord metabÃlitos. l-alanil-glutamina medula espinhal
ACESSO AO ARTIGO
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5458Documentos Relacionados
- Pré-condicionamento com L-alanil-glutamina reduz a lesão de isquemia-reperfusão no fígado de ratos
- Efeitos metabólicos da L-alanil-glutamina em ratos submetidos à isquemia da pata traseira esquerda seguida de reperfusão
- Efeitos da l-alanil-glutamina na isquemia e reperfusÃo em cÃrebro de ratos wistar
- PrÃ-condicionamento com l-alanil-glutamina na lesÃo aguda de isquemia e reperfusÃo cerebral em gerbils
- Pré-tratamento com o dipeptídeo L-Alanil-glutamina atenua a lesão por isquemia e reperfusão no testículo do rato