Efeitos da isquemia/reperfusão intestinal sobre o receptor P2X2 e neurônios entéricos do íleo de ratos. / Effects of intestinal ischemia/reperfusion on P2X2 receptor and enteric neurons of the rats ileum.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

09/12/2011

RESUMO

The acute mesenteric ischemia is a vascular condition of extreme emergency, which is fatal in the world population by 60% to 80% of cases. The aim of this work was to study the effects of intestinal ischemia/reperfusion on the P2X2 receptor and different neuronal classes in the myenteric plexus. We analyzed the ileum of rats: control, Sham and ischemia/reperfusion (I/R-i) with 24 hours and 1 week of reperfusion. The colocalization were performed by P2X2 receptor with NOS, ChAT, Calb, Calr, S100 and anti-HUC/D. The results showed a decrease of P2X2-ir neurons colocalizated with ChAT and Hu, and an increase in the group with S100 in the I/R-i 1 week group. The density of cells showed an increase of P2X2-ir and S100 and a decrease of Hu and ChAT in I/R-i 1 week group. The profile area showed an increase in NOS-ir, ChAT-ir, Calb (Dogiel Type II) and Calr-ir neurons. We conclude that ischemia led to different changes in P2X2 receptor, enteric neurons and glial cells, which can cause gastrointestinal disorders, such as intestinal motility disorder.

ASSUNTO(S)

enteric nervous system gastrointestinal motility Íleo ileum ischemia isquemia motilidade gastrointestinal myenteric plexus neurônios neurons plexo mioentérico sistema nervoso entérico

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