Dopamine-dependent synaptic plasticity in striatum during in vivo development
AUTOR(ES)
Tang, Ka-Choi
FONTE
The National Academy of Sciences
RESUMO
The neurotransmitters dopamine (DA) and glutamate in the striatum play key roles in movement and cognition, and they are implicated in disorders of the basal ganglia such as Parkinson's disease. Excitatory synapses in striatum undergo a form of developmental plasticity characterized by a decrease in glutamate release probability. Here we demonstrate that this form of synaptic plasticity is DA and DA D2 receptor dependent. Analysis of spontaneous synaptic responses indicates that a presynaptic mechanism involving inhibition of neurotransmitter release underlies the developmental plasticity. We suggest that a major role of DA in the striatum is to initiate mechanisms that regulate the efficacy of excitatory striatal synapses, producing a decrease in glutamate release.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=14741Documentos Relacionados
- Age-Related Dopamine-Dependent Disorders
- Dopamine-dependent responses to morphine depend on glucocorticoid receptors
- Quantitative correlation of dopamine-dependent adenylate cyclase with responses to levodopa in various mice.
- Isolated horizontal cells from carp retina demonstrate dopamine-dependent accumulation of cyclic AMP.
- Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
