DNA-binding proteins present in varicella-zoster virus-infected cells.

AUTOR(ES)

Roberts, C R

RESUMO

DNA-binding proteins present in varicella-zoster virus-infected cells were identified by DNA-cellulose chromatography of radioactively labeled cell extracts. Seven virus-specific proteins, ranging in molecular weight from approximately 175,000 to 21,000, showed affinity for single- or double-stranded DNA or both. These proteins include the varicella-zoster virus major capsid protein, a phosphorylated tegument protein, and a 125,000-molecular-weight species which may be analogous to the major DNA-binding protein of herpes simplex virus. We also identified a number of DNA-binding phosphoproteins by these procedures. Finally, protein blot studies were carried out to determine whether these proteins bind preferentially to virus rather than to host cell DNA.

Documentos Relacionados

• Deoxypyrimidine nucleoside metabolism in varicella-zoster virus-infected cells.
• Selective anabolism of 6-methoxypurine arabinoside in varicella-zoster virus-infected cells.
• Localization of Varicella-Zoster Virus Gene 21 Protein in Virus-Infected Cells in Culture
• Human polymorphonuclear leukocyte-mediated cytotoxicity against varicella-zoster virus-infected fibroblasts.
• Antibody-dependent cell-mediated cytotoxicity against varicella-zoster virus-infected targets.